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The Influence of Luofengning-2 on the Quality of Life in Patients with Cardiorenal Syndrome
Pages: 1829-1835
Year: Issue:  16
Journal: Research of Traditional Chinese Medicine

Keyword:  cardiorenal syndromeLuofengning-2quality of lifeMinnesota living with heart failure questionnaire6-minute walk test;
Abstract: Objective To investigate the effect of Luofengning-2(LFNP-2)to the quality of life in patients with cardiorenal syndrome.Methods According to the randomised controlled principle,there was a total of 120 cases of patients with cardiorenal syndrome(CRS).Among them,there were only 104 qualified patients(The loss rate was 13.33%in this clinical study).One hundred and four patients with CRS were randomly divided into the LFNP-2 group(n =35),the remove expelling wind drug group(n =36)and the western medicine group(n =33).Medication for two months.The standard of curative effect evaluation,Minnesota Living With Heart Failure Questionnaire(MLHFQ),6-minute walk test,the typical symptom quantitative score of heart and kidney changes were used as the index for appraising quality of life before and after the treatment respectively.Results We regard changes of NYHA cardiac functional classification as efficacy index.After treatment,the difference of total efficiency of three groups was not statistically significant(P >0.05),but the total efficiency of three groups from large to small order:the LFN-2 group,the remove expelling wind drug group,western medicine group.After treatment,MLHFQ score of three groups was statistically significant(P <0.05 or P <0.01)compared with before,the western medicine group appeared a increasing trend.Comparison among groups,the score of LFNP-2 group was the lowest by the obvious improvement and the difference was statistically significant(P <0.05).Comparison before and after treatment among in LFNP-2 group,6-minute walking distance was prolonged,the difference was statistically significant(P <0.01).Comparison among groups,there was no obvious improvement and the difference was not statistically significant(P >0.05).After treatment,the edema symptom score of LFNP-2 group reduced obviously(P <0.05)compared with before.Comparison among groups,the score of LFNP-2 group was the lowest by the obvious improvement and the difference was statistically significant(P <0.05).After 2 months,the other symptom score of three groups has no statistically significance(P >0.05).That is not obvious symptoms improvement before and after treatment about themselves.Comparison before and after treatment,left ventricular ejection fraction(LVEF),left ventricular dimension in systole(LVDs),left ventricular dimension at enddiastole(LVDd),E/A ratio(E/A)of three groups has no statistically significance(P >0.05).Conclusion LFNP-2 is effective to a certain extent in the treatment of CRS patients.LFNP-2 can prolong 6-minute walking distance,reduce MLHFQ score and edema symptom score,improve the life quality of CRS patients.
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