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nao xin tong jiao nang dui tang niao bing xin nao xue guan bing fa zheng bing ren imt nei pi gong neng de ying xiang
Author(s): 
Pages: 1951-1952
Year: Issue:  16
Journal: Research of Traditional Chinese Medicine

Keyword:  糖尿病心脑血管并发症脑心通胶囊内皮功能血管黏附分子-1细胞间黏附分子-1消渴;
Abstract: 目的观察脑心通胶囊对糖尿病心脑血管并发症病人颈动脉内-中膜厚度(IMT)、内皮功能的影响。方法将100例糖尿病心脑血管并发症病人随机分为治疗组和对照组,每组50例。对照组低盐低脂糖尿病饮食,给予降糖、降脂等治疗,合并冠心病病人治疗给予硝酸酯类、β受体阻滞剂、阿司匹林等治疗。治疗组在对照组的基础上加用脑心通胶囊4粒,每天3次口服,共治疗4周。治疗前后使用彩色多普勒超声诊断仪检查颈动脉,测定颈总动脉内膜厚度,计算左右IMT均值,ELISA法检测血清血管黏附分子-1(sVCAM-1)、细胞间黏附分子-1(sICAM-1),放射免疫法检测血清内皮素-1(ET-1)水平。结果两组治疗前IMT、sVCAM-1、sICAM-1、ET-1水平差异无统计学意义(P>0.05),治疗后均明显降低,与治疗前比较有统计学意义(P<0.05),且治疗组治疗后与对照组治疗后有统计学意义(P<0.05)。结论脑心通胶囊对糖尿病心脑血管并发症病人有较好的治疗作用,能显著改善病人内皮功能,对于延缓糖尿病病人动脉硬化的发生及进程,提高生活质量。
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