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The alteration of Th17 cells, Treg cells and some related cytokines in peripheral blood of patients with RBC transfusion failure
Author(s): GAO Yong, SONG Yue, HAN Shukun, FAN Yaxin
Pages: 601-
604
Year: 2016
Issue:
6
Journal: Chinese Journal of Blood Transfusion
Keyword: invalid RBC transfusion; Th17 cells; Treg cells;
Abstract: 目的 研究Th17细胞和Treg细胞及相关细胞因子在红细胞输注无效患者外周血中的水平变化.方法 采用流式细胞术检测36名反复输注红细胞患者(分为无效组和有效组)外周血中Th17及Treg细胞的变化,采用ELISA方法检测血清中IL-6、IL-23、IL-17和TGF-β的浓度.结果 输注无效组患者输血后Th17细胞、IL-6、IL-23和IL-17水平较输血前明显升高(P<0.05),Treg细胞和TGF-β水平较输血前明显降低(P<0.05),差异有统计学意义;有效组患者Th17、Treg、IL-6、IL-23、IL-17和TGF-β水平无改变(P>0.05).结论 红细胞输注无效患者的免疫系统处于活跃状态,Th17、Treg、IL-6、IL-23、IL-17和TGF-β水平变化,这些原因可能参与红细胞输注无效免疫发病过程.
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