Clinical Analysis of Paraneoplastic Limbic Encephalitis
Author(s): LI Bo, YAN Jia-lan, ZHU Yan-xia, FENG Lian-yuan, WANG Xue-li
Pages: 55-57
Year: 2016 Issue: 9
Journal: Clinical Misdiagnosis & Mistherapy
Keyword: Limbic encephalitis; Misdiagnosis; Hyponatremia; Brain infarction;
Abstract: Objective To investigate the clinical features of paraneoplastic limbic encephalitis (PLE) and improve clinical diagnosis and treatment. Methods Clinical data, neural electrophysiological and imaging features of 3 PLE patients were retrospectively analyzed. Results The 3 patients were admitted for cognitive disorders, epilepsy, abnormal mental or behavior disorder and impaired consciousness. Hyponatremia was discovered in 2 patients with difficulty to correct. 1 patient once was ineffectively treated for cerebral infarction and viral encephalitis with antiplatelet aggregation, neurotrophic, anti-atherogenic, anti-free radicals, promoting circulation and antiviral therapy. The 3 patients were diagnosed via cerebrospinal fluid examination, electroencephalogram, lung CT and brain MRI, and they were diagnosed as having PLE. Symptoms were controlled or alleviated following Glucocorticoids and neuroprotection treatment. 1 patient was transferred to the surgical de-partment for treatment. Conclusion Early diagnosis can be made based on special clinical manifestations, brain MRI and tumor-related inspection to prevent misdiagnosis and mistreatment.
Pages: 55-57
Year: 2016 Issue: 9
Journal: Clinical Misdiagnosis & Mistherapy
Keyword: Limbic encephalitis; Misdiagnosis; Hyponatremia; Brain infarction;
Abstract: Objective To investigate the clinical features of paraneoplastic limbic encephalitis (PLE) and improve clinical diagnosis and treatment. Methods Clinical data, neural electrophysiological and imaging features of 3 PLE patients were retrospectively analyzed. Results The 3 patients were admitted for cognitive disorders, epilepsy, abnormal mental or behavior disorder and impaired consciousness. Hyponatremia was discovered in 2 patients with difficulty to correct. 1 patient once was ineffectively treated for cerebral infarction and viral encephalitis with antiplatelet aggregation, neurotrophic, anti-atherogenic, anti-free radicals, promoting circulation and antiviral therapy. The 3 patients were diagnosed via cerebrospinal fluid examination, electroencephalogram, lung CT and brain MRI, and they were diagnosed as having PLE. Symptoms were controlled or alleviated following Glucocorticoids and neuroprotection treatment. 1 patient was transferred to the surgical de-partment for treatment. Conclusion Early diagnosis can be made based on special clinical manifestations, brain MRI and tumor-related inspection to prevent misdiagnosis and mistreatment.
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