Author(s): ZHANG Tingrong, LU Xiangdong, CAI Hongchuan, Department of Oncology, Affiliated Jiangyin Hospital, Medical College of Southeast University
Pages: 1772-1775
Year: 2016 Issue:  16
Journal: Jiangsu Medical Journal
Keyword:  CTEN protein; Transforming growth factor-β1; E-cadherin; Non-small cell lung cancer;
Abstract: Objective To explore the expressions and clinical significance of CTEN protein,transforming growth factor(TGF)-β1 and E-cadherin in non-small cell lung cancer(NSCLC).Methods The expressions of CTEN,TGF-β1 and E-cadherin in cancer tissues were detected by immunohistochemistry in 120 patients with NSCLC.The relationship of the expressions and clinicopathological cheracteristics was analyzed.Results The positive rates of CTEN protein,TGF-β1and E-cadherin in NSCLC tissues were 68.3%,48.3% and 29.2%,respectively,which were closely related with tumor size,histological grade TNM staging and lymph node metastasis(P<0.05).A significant correlation was confirmed between the expression of CTEN protein and TGF-β1(r=0.264,P=0.004),or between TGF-β1 and E-cadherin(r=-0.254,P=0.005).Kaplan-Meier survival analysis showed that a high expression level of CTEN resulted in a significantly poor prognosis of the patients with NSCLC.Multivariate Cox regression analysis showed that CTEN expression in NSCLC was an independent prognostic factor(P<0.05).Conclusion The expressions of CTEN protein,TGF-β1 and E-cadherin may contribute to the occurrence and development of NSCLC and have a certain significance in predicting the prognosis of the patients with NSCLC.