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Relation between animal models of RA and clinic
Author(s):
ZHANG Lingling
,
SHEN Yuxian
,
WEI Wei
Pages:
502
-
506
Year:
2002
Issue:
5
Journal:
CHINESE PHARMACOLOGICAL BULLETIN
Keyword:
类风湿关节炎
;
佐剂性关节炎
;
胶原诱导性关节炎
;
Abstract:
类风湿关节炎(rheumatoid arthritis,RA)动物模型特别是大鼠佐剂性关节炎模型和小鼠胶原诱导性关节炎模型与人RA在发病机制、临床表现等有着相似的特点,是研究RA、筛选抗炎免疫药物较理想的病理模型.探讨RA动物模型的发病机制及其与临床的关系,对进一步了解RA的病理、生理、神经内分泌免疫等特点;对寻找安全有效的治疗RA的药物十分重要.该文就几种RA动物模型的建立、病理特征、临床表现等方面进行了论述.
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