Author(s): CHENG Jing-chao, FAN Shi-yong, ZHONG Bo-hua, SHI Wei-guo, ZHANG Ya-tong, Hebei University of Science and Technology, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
Pages: 692-696
Year: 2016 Issue:  4
Journal: International Journal of Pharmaceutical Research
Keyword:  resveratrol; derivatives; chemical modification; lead compound;
Abstract: Natural product resveratrol has antioxidation,cardiovascular protection and many other useful biological activities.In recent years,many researchers have paid more and more attention to it. However it cannot be used as candidate for the development of new drug due to its poor druggability. Novel resveratrol derivates with improved water solubility and highly potent biological activity could be obtained by chemical modifying of chemical structure of resveratrol. Researches have shown that resveratrol derivatives exhibit many kinds of attractive activities,including antitumor,reducing blood fat,antiviral,anti-neurodegenerative diseases and so on,which makes them could be used as leads for the further developing of new drugs. This review discusses the development of novel resveratrol derivatives by chemical modification in recent years..