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nao xue shu kou fu ye dui da shu nao chu xue hou shen jing gong neng ji xue zhong zhou wei ban an dai xi bao diao wang de ying xiang
Author(s): 
Pages: 1735-1737
Year: Issue:  15
Journal: Research of Traditional Chinese Medicine

Keyword:  脑出血脑血疏口服液细胞凋亡神经功能缺失大鼠中风;
Abstract: 目的在建立大鼠脑出血(ICH)模型基础上,早期应用药物进行干预,观察大鼠神经功能缺失及脑出血血肿周围半暗带中细胞凋亡情况。方法选用SD大鼠78只,随机分为实验组、治疗组和对照组,各组又随机分为1h、6h、1d、3d、7d和14d亚组。实验组注射Ⅳ型胶原酶建立ICH模型,治疗组予以药物干预,后各组分别进行神经功能测定及TUNEL法统计检测细胞。结果脑出血模型建立后各组动物均出现不同的神经功能缺失症状,脑出血组神经功能缺失症状明显重于治疗组和对照组;对照组脑组织几乎未见TUNEL阳性细胞,实验组于6h可见脑出血灶周围TUNEL阳性细胞最多,并随时间的延长逐渐减少,于3d再次出现TUNEL阳性细胞高峰后下降;治疗组仅在脑出血后6h观察到脑出血灶周围TUNEL阳性细胞数高峰,但其高峰时数量少于脑出血组,之后渐下降。结论脑血疏口服液可以通过抑制神经元凋亡,改善神经功能缺失及减轻脑出血后继发脑损害。
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