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xin mai long zhu she ye dui man xing xin li shuai jie bing ren xin gong neng he yan xing yin zi shui ping de ying xiang
Author(s): 
Pages: 1762-1764
Year: Issue:  15
Journal: Research of Traditional Chinese Medicine

Keyword:  心力衰竭心脉隆注射液高敏-C反应蛋白N末端脑钠肽前体炎性因子心悸;
Abstract: 目的探讨心脉隆对慢性心力衰竭(CHF)病人心功能及炎性因子水平的影响。方法 68例慢性心力衰竭病人随机分为常规治疗组和心脉隆组。常规治疗组使用洋地黄、利尿剂、硝酸酯类等药物常规治疗;心脉隆组在常规治疗的基础上加用心脉隆注射液,两组均以10d为1个疗程。治疗前后测量血压、心率、血生化指标,评定心功能,检查超声心动图,检测N末端脑钠肽前体(NT-proBNP)、高敏C-反应蛋白(hs-CRP)、血浆白细胞介素(IL-18)、IL-10水平。结果治疗10d后,常规治疗组和心脉隆组病人hs-CRP、NT-proBN P、IL-18及均较治疗前明显下降(P<0.01),IL-10、LVEF较治疗前显著升高(P<0.01);心脉隆组治疗后血hs-CRP、NT-proBN P及IL-18组较常规治疗组治疗后明显下降(P<0.01),LVEF、IL-10、较治疗前显著升高(P<0.01)。结论慢性心力衰竭病人按常规治疗后IL-10、LVEF明显提高,IL-18、hs-CRP、NT-proBN P显著下降;而加用心脉隆能够进一步提高病人的IL-10、LVEF,使hs-CRP、IL-18和NT-proBNP进一步下降,表明心脉隆能更有效治疗心衰,改善病人预后。
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