Association of HbA1c Levels with Carotid Plaque in Community-based Population with Type 2 Diabetes
Author(s): ZHANG Run-Hua, LIU Gai-Fen, WANG Yi-Long, PAN Yue-Song, JIANG Yong, LI Bo-Hong, TIAN Rui, ZHANG Guo-Jun, CHEN Yan, LIN Jin-Xi, TIAN Ai-Hong, DONG Li-Guang, HAO Chun-Yi, SHEN Ling-Xia, WANG Yong-Jun
Pages: 659-664
Year: 2016 Issue: 8
Journal: Chinese Journal of Stroke
Keyword: HbA1c; Carotid plaque; Diabetes;
Abstract: Objective To evaluate the association of HbA1c and carotid plaque in community-based type 2 diabetes.
Methods Form the cross-sectional study, information of community-dwelling adults was collected by investigators who were trained uniformly, including demographics, behavior and life style, disease history, medicine condition, HbA1c level, as well as carotid ultrasound. A total of 552 subjects, who self-reported be with type 2 diabetes or had glucose-lowering agents and ≥40 years old, were included. The association of HbA1c level and carotid plaque was explored by using the methods of univariate and multivariate logistic regression models. In addition, stratiifed analysis was used to evaluate the risk of HbA1c level and carotid plaque in population with different characteristics.
Results There were 218 men and 334 women in this study, of which the prevalence of carotid plaque was 41.9% and the mean level of HbA1c was (7.25±1.53)%. In the univariate logistic regression model, the odds ratio of carotid plaque was 1.10 (95%CI 0.98-1.22,P=0.108) for per 1% increase. TheOR was 1.13 (95%CI 1.00-1.26,P=0.047) when adjusting age and gender. After disease history, smoking status, drinking, total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL), statins, BMI, physical exercises, medicine treatment, sleep duration, and family history of stroke have been taken into consideration, theOR was 1.16 (95%CI 1.02-1.33,P=0.025) for per 1% increase. When the level of HbA1c was classified as low group, middle group, and high group, serving low group as reference, theOR of high group was 1.71 (95%CI 1.06-2.76,P=0.028), and theOR of middle group was 1.40 (95%CI 0.87-2.25,P=0.170). Stratiifed by age, BMI, and hypertension, the population of <60 years or BMI≥24 or with hypertension were found tending to have relative high risk of association of HbA1c and carotid plaque.
Conclusion HbA1c level is signiifcantly associated with carotid plaque in the community-dwelling with type 2 diabetes.
Pages: 659-664
Year: 2016 Issue: 8
Journal: Chinese Journal of Stroke
Keyword: HbA1c; Carotid plaque; Diabetes;
Abstract: Objective To evaluate the association of HbA1c and carotid plaque in community-based type 2 diabetes.
Methods Form the cross-sectional study, information of community-dwelling adults was collected by investigators who were trained uniformly, including demographics, behavior and life style, disease history, medicine condition, HbA1c level, as well as carotid ultrasound. A total of 552 subjects, who self-reported be with type 2 diabetes or had glucose-lowering agents and ≥40 years old, were included. The association of HbA1c level and carotid plaque was explored by using the methods of univariate and multivariate logistic regression models. In addition, stratiifed analysis was used to evaluate the risk of HbA1c level and carotid plaque in population with different characteristics.
Results There were 218 men and 334 women in this study, of which the prevalence of carotid plaque was 41.9% and the mean level of HbA1c was (7.25±1.53)%. In the univariate logistic regression model, the odds ratio of carotid plaque was 1.10 (95%CI 0.98-1.22,P=0.108) for per 1% increase. TheOR was 1.13 (95%CI 1.00-1.26,P=0.047) when adjusting age and gender. After disease history, smoking status, drinking, total cholesterol, triglyceride, low-density lipoprotein (LDL), high-density lipoprotein (HDL), statins, BMI, physical exercises, medicine treatment, sleep duration, and family history of stroke have been taken into consideration, theOR was 1.16 (95%CI 1.02-1.33,P=0.025) for per 1% increase. When the level of HbA1c was classified as low group, middle group, and high group, serving low group as reference, theOR of high group was 1.71 (95%CI 1.06-2.76,P=0.028), and theOR of middle group was 1.40 (95%CI 0.87-2.25,P=0.170). Stratiifed by age, BMI, and hypertension, the population of <60 years or BMI≥24 or with hypertension were found tending to have relative high risk of association of HbA1c and carotid plaque.
Conclusion HbA1c level is signiifcantly associated with carotid plaque in the community-dwelling with type 2 diabetes.
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