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Mutagenic Analysis of Five Haloacetamides Disinfection By-products in the Tk Gene of Mouse Lymphoma Cells
Author(s): 
Pages: 153-158
Year: Issue:  1
Journal: Asian Journal of Ecotoxicolog

Keyword:  haloacetamidemouse lymphoma cellsmutation assay;
Abstract: 卤代乙酰胺类(HAcAm)消毒副产物(DBPs)是饮用水中新兴含氮类DBPs之一.为探究HAcAms的致突变性,选择小鼠淋巴瘤细胞作为受试细胞,分别考察了一氯代乙酰胺、二氯代乙酰胺、三氯代乙酰胺、一碘代乙酰胺、二碘代乙酰胺(DIAcAms)共5种HAcAms对小鼠淋巴瘤细胞Tk基因突变的影响.结果表明,在0.05~20 μmol·L-1暴露浓度下,5种HacAms类DBPs对小鼠淋巴瘤细胞呈现出一定的细胞毒性,随着暴露浓度的升高,细胞毒性增强.暴露4h后,5种HacAms中只有DIAcAms呈现出显著的致突变性(暴露剂量高于5 μmol·L-1),且以小集落为主.上述研究结果为研究HacAms对哺乳动物细胞的致突变作用提供了基础数据.
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