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Toxic Effects of Acrylamide on Zebrafish Organs and DNA Damage of Germ Cell
Author(s): 
Pages: 382-388
Year: Issue:  1
Journal: Asian Journal of Ecotoxicolog

Keyword:  acrylamidezebra fishoxidative damageDNA damage;
Abstract: 在我国,聚丙烯酰胺(PAM)主要应用于石油开采,其长期暴露于环境中可以降解成有毒的丙烯酰胺(AM).为探究在降解过程中AM的毒性作用,选择斑马鱼作为受试动物,进行AM长期毒性暴露40 d,考察了对斑马鱼的肝脏、脑组织、心脏、腮等器官的影响情况.结果表明:在2.04 mg·L-1、6.12 mg·L-1和18.36 mg·L-1暴露浓度下,形态学观察斑马鱼的鳃丝,鳃小片和鳃细胞有严重的受损现象;随着浓度的升高斑马鱼肝脏、脑组织和心脏中MDA含量、LDH活力的升高,SDH和Na+-K+-AT-Pase活力的降低,均对其肝脏、脑组织和心脏造成氧化损伤作用,从而影响了斑马鱼体内细胞能量代谢过程.采用彗星试验检测斑马鱼的生殖腺细胞DNA损伤,结果显示暴露于浓度为2.04 mg·L-1 ~ 18.36 mg·L-1的AM后,斑马鱼的DNA损伤均表现为显著差异(P<0.01).上述研究结果均确定了AM对斑马鱼的毒性效应并可造成其生殖腺细胞的DNA损伤.
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