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Stability of efficacy composition content of different thymopentins
Pages: 87-94
Year: Issue:  4
Journal: Acta Scientiarum Naturalium Universitatis Sunyatseni

Keyword:  thymopentinstabilityhigh performance liquid chromatography (HPLC)injectionsolid preparation;
Abstract: Reversed phase high performance liquid chromatography was used to analyze three types of the 10 batches thymopentin preparation:water injection,powder injection and solid preparation,and their efficacy assessments were processed through composition content determination.The result indicated that the efficacy composition contents of water and powder injection drugs were higher than that of solid prepa-ration.This could be due to water and powder injection preparation forms were sterile products.The thy-mopentin composition was not easy to decompose and metamorphic with single matrix components under aseptic conditions.Several factors are not conducive thymopentin solid preparation to stability:solid preparation as enteric-coated troche are non-sterile products,in addition,the troche of the corresponding supplementary material composition is complex relatively.The ingredient material make the thymopentin solid preparation composition stable,and the efficacy could be developed.The high value for application could be obtained by improve the bioavailability thymopentin solid preparation.
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