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Clinical Efficacy of Taxinol Combined with Anthracycline Regimen for Breast Cancer Preoperative Chemotherapy
Author(s): Qu Yanhong, Yang Ke
Pages: 60-
63
Year: 2016
Issue:
13
Journal: China Pharmaceuticals
Keyword: advanced breast cancer; taxinol; anthracycline; preoperative chemotherapy;
Abstract: Objective To study the clinical efficacy of combination of taxinol combined with anthracycline for advanced breast cancer preoperative chemotherapy. Methods 82 patients with unilateral primary breast cancer were selected and divided into two groups based on different chemotherapy regimens. 41 cases in control group received the cyclophosphamide and epirubicin ( EC ) chemotherapy regi-men, and 41 cases in combination group received taxinol and anthracycline regimen. 12 months after treatment, local evaluations of breasts, oxter and clavicle lymph nodes were carried out via Doppler ultrasonography, and systemic evaluations were realized by CT and bone scan. The pCR ( complete remission ) , CR+PR ( objective response rate ) and lymph node negative rate were compared in two groups. Results Follow-up visit and therapeutic effect evaluation were conducted during 12 months after treatment, the results showed that the CR+PR ( objective response rate ) in combination group was significantly higher than that of control group, with a statistically significant difference ( P < 0. 05 ); in combination group, there were no significant differences in CR+PR rate of TA or TAC method than that of TE or TEC method ( P > 0. 05 );the pCR ( complete remission ) in combination group was significantly higher than that of control group, with a statistically significant difference ( P < 0. 05 ); in combination group, there were no significant differences in pCR ( complete remission ) between TA or TAC method and TE or TEC method ( P > 0. 05 ) . No statistically significant differences were found in lymph node negative rate between combination and control group ( P > 0. 05 ) . Conclusion The clinical efficacy of taxinol combined with anthracycline regimen for breast cancer preoperative chemotherapy is more significant than the chemotherapy regimen of cyclophos-phamide and epirubicin ( EC ) .
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