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Effect of pirarubicin and gemcitabine intravesical chemotherapy on the recurrence and postoperative survival of bladder cancer patients
Author(s): DONG Sheng-fang, Department of Urology Surgery, Zhongshan Hospital Affiliated to Dalian University
Pages: 839-
841
Year: 2016
Issue:
7
Journal: Chinese Journal of Clinical Oncology and Rehabilitation
Keyword: Bladder neoplasms; Gemcitabine; Pirarubicin; Chemotherapy; Survival;
Abstract: Objective To explore the effect of pirarubicin and gemcitabine and intravesical chemotherapy on the recurrence and postoperative survival of bladder cancer patients. Methods From February2011 to May 2013 in Dalian University Affiliated Zhongshan Hospital,78 cases of bladder cancer were selected and devided to observation group and control group,with 39 cases in each group. Patients in observation group were received immediate postoperative instillation of gemcitabine to bladder; while patients in control group were received immediate postoperative instillation of pirarubicin to bladder. The rate of adverse reactions during treatment were compared in the two groups. After 2 years of follow-up,the number of survival and recurrence cases were recorded. Results After 2 years,patients in two groups were all survival,and survival rate was 100. 0%. Recurrence rate of patients in the observation group was 23. 1%,which was25. 6% in the control group,and the difference had no statistical significance( P > 0. 05). Adverse reaction rate of patients in the treatment group was 12. 8%,which was significantly lower than that in the control group( 30. 8% 0,and the difference was statistically significant( P < 0. 05). Conclusions Compared with pirarubicin,the application of gemcitabine chemotherapy treatment in patients with bladder cancer have a significant effect,but which produce fewer adverse reactions,and therefore reduce the suffering of patients.It is worth clinical promotion.
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