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Value of alpha-fetoprotein-L3 proportion in the efficacy evaluation of hepatocellular carcinoma with transcatheter arterial chemoembolization
Author(s): WEI Jian-zhu, TAN Yu-lin, Department of Interventional Radiology, Affiliated Hospital of Bengbu Medical College
Pages: 810-
813
Year: 2016
Issue:
7
Journal: Chinese Journal of Clinical Oncology and Rehabilitation
Keyword: Hepatocellular neoplasms; Alpha-fetoprotein; Alpha-fetoprotein variants; Microcentrifuge column method; Electrochemiluminescence immunoassay;
Abstract: Objective To explore the clinical value of alpha-fetoprotein( AFP)-L3 proportion in the efficacy evaluation of hepatocellular carcinoma with transcatheter arterial chemoembolization( TACE).Methods Component AFP-L3 was isolated by using microcentrifugal column method,and the amount of serum AFP and AFP-L3 was detected by electrochemiluminescence immunoassay( ECLIA),thereafter,AFP-L3 quantity / AFP volume( AFP-L3) was calculated. AFP-L3( 10% was used as a positive criterion.To culture the value of AFP-L3 in the evaluation of TACE efficacy,the AFP and AFP-L3 level before and after TACE were compared in 50 cases,the imaging performance of Digital Subtraction Angiography( DSA)was combined,the value of AFP-L3 in the evaluation of TACE was analysised. Results When tumor responses were evaluated using the modified Response Evaluation Criteria in Solid Tumors( RECIST) criteria,the numbers of the patients achieved complete response( CR),partial response( PR),stable disease( SD),progressive disesse( PD) were 7,15,10,18 respectively. In the group of CR + PR + SD + PD,the difference between preoperative AFP and postoperative AFP was not statistically significant( P > 0. 05); the difference between preoperative AFP-l3 and postoperative AFP-l3 was statistically significant( P < 0. 01).In the group of CR + PR + SD,the difference between preoperative AFP and postoperative AFP was statistically significant( P < 0. 05); the difference between preoperative AFP-l3 and postoperative AFP-l3 was statistically significant( P < 0. 01). AFP and AFP-L3 percentage reduction compared by paired sample Wilcoxon signed rank test,and the difference was statistically significant( P < 0. 01). Conclusion AFP-L3 is a more accurate tumor marker in the evaluation of the efficacy of hepatocellular carcinoma after TACE compared with AFP.
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