Author(s): LI Hu-ying
Pages: 150-151
Year: 2016 Issue:  14
Journal: China Foreign Medical Treatment
Keyword:  Loop electrosurgical excision procedure; Interferon; Cervical intraepithelial neoplasias;
Abstract: Objective To observe the clinical curative effect of Leep knife and interferon in treatment of cervical intraep-ithelial neoplasias. Methods 118 cases of patients with cervical CIN of grade Ⅱ and Ⅲ admitted and treated in our hospi-tal from February 2011 to October 2015 were selected as the research objects and randomly divided into two groups, the control group (56 cases) were treated with simple loop electrosurgical excision procedure (Leep knife), the observation group (62 cases) were treated with recombinant interferon α-2b before the LEEP knife treatment, and the clinical curative effect, immune globulin and T cell subset levels were compared between the two groups after 6-month treatment. Results The dif-ference in the total effective rate between the control group and the observation group had statistical significance by com-parison at the end of the treatment, [71.4% (40/56) vs 93.5% (58/62)], (χ2=10.2275, P<0.01), after 1-year follow-up, recur-rence occurred to 4 cases in the control group and recurrence occurred to 0 case in the observation group, and the differ-ences in the intraoperative blood loss and average healing time between the control group and the observation group had statistical significance by comparison, [(10.5±3.5) ml, (5.5±1.5) weeks vs (5.0±1.5) ml, (4.0±0.5) weeks], P<0.05, in addition, the IgA, ,IgG and IgM contents in serum and CD4+ T cell ratio in the observation group were higher than those in the con-trol group, but the CD8+ T cell ratio in the observation group was lower than that in the control group. Conclusion Loop electrosurgical excision procedure and interferon treatment can effectively improve the clinical curative effect of CIN and immunologic function, which is an ideal treatment method.