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Effect of Erythropoietin on Vascular Remodeling after Carotid Artery Balloon Injury in Rats
Pages: 1-4,107
Year: Issue:  2
Journal: Acta Academiae Medicinae Jiangxi

Keyword:  erythropoietinvascular remodelinginflammatory factorsanimalslaboratory;
Abstract: ABSTRACT:Objective To explore the effect of erythropoietin(EPO)on vascular remodeling af-ter carotid artery balloon injury.Methods Seventy-five SD rats were randomly divided into five groups,with 15 rats in each group.The sham operation was performed in control group.The PT-CA balloon catheter was used to establish the animal model as the positive group via injuring ca-rotid artery intima.Then,model rats were treated with intraperitoneal injection of 3000 U·kg-1 EPO alone or in combination with smearing pluronic gel containing 0.5 mg·mL-1 transforming growth factor beta1(TGF-β1)or 0.5 mg·mL-1 matrix metalloproteinase-2(MMP-2)on carotid adventitia.The neointimal thickness,intima/media area ratio,expression of collagen,TGF-β1 and MMP-2,and serum levels of vascular endothelial growth factor(VEGF)and tumor necrosis fac-tor-α(TNF-α)were detected on days 1,7 and 14 after operation.Results Compared with control group,the neointimal thickness,intima/media area ratio,and expression of collagen,TGF-β1 and MMP-2 significantly increased in positive group.Compared with positive group,these parameters significantly decreased in EPO group.However,the effect of EPO was reversed by TGF-β1 and MMP-2.Conclusion EPO can inhibit vascular restenosis following carotid artery balloon injury in rats through attenuating intimal hyperplasia and collagen expression.The weakened expression of inflammatory factors,such as TGF-β1,MMP-2,VEGF and TNF-α,maybe one of the important mechanisms of EPO action.
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