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Relationships of Sporadic and Recurrent Spontaneous Abortion to Cytogenetic Abnormalities
Author(s): 
Pages: 39-41,48
Year: Issue:  2
Journal: Acta Academiae Medicinae Jiangxi

Keyword:  early spontaneous abortionchorionic villus cellskaryotypingsporadicrecurrent;
Abstract: Objective To investigate the relationships of sporadic and recurrent spontaneous a-bortion to cytogenetic abnormalities.Methods According to the number of abortion,178 preg-nant women with early spontaneous abortion((28.0±3.2)years of age)were divided into spo-radic spontaneous abortion group (n = 90,sporadic group)and recurrent spontaneous abortion group(n=88,recurrent group).The chorionic villi were obtained in uterine curettage and were cultured in situ for karyotyping.Results In sporadic group,chorionic villus culture was success-ful in 87 cases and unsuccessful in 3 cases.Among the 87 cases,39(45%)had chromosome nu-merical abnormalities,and 92% of them(36/39)had numerical abnormalities.In recurrent group, chorionic villus culture was successful in 86 cases and unsuccessful in 2 cases.Among the 86 ca-ses,48(56%)had chromosome numerical abnormalities,and 90% of them(43/48)had numerical numerical abnormalities.There were no significant differences in the rates of abnormal karyotype and type between the two groups(P >0.05).Conclusion Chromosomal numerical numerical ab-normalities,but not maternal age,are the primary cause of early spontaneous abortion.However, chromosome numerical abnormalities are not correlated with the number of abortion.The causes of recurrent embryonic chromosome numerical abnormalities need to be further studied.
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