Author(s): LI Xue-rong, HE Yong, LEI Yu-jia, QIN Xi-he, WEI Qing-tao, PAN Xin-min, LI Li-juan, ZHANG Lin
Pages: 94-96,104
Year: 2016 Issue:  2
Journal: Journal of Forensic Medicine
Keyword:  forensic pathology; coronary arteriosclerosis; m yocardium; phosphatase and tensin hom olog deleted on chrom osom e ten;
Abstract: Objective To observe the expression of phosphatase and tensin hom ology deleted on chrom o-som e ten (PTEN) in m yocardial tissue in patients w ith coronary heart disease, and explore the relevance betw een the expression of PTEN and the occurrence and developm ent of coronary heart disease. Methods A total of 16 death cases w ith pathological diagnosis of coronary heart disease w ere collected as experi-m ental group, and 19 cases w ithout m yocardial lesions w ere selected as control group. The expression of PTENprotein and its m RNA w ere detected by im m unohistochem istry and real-tim e fluorescence quanti-tative PC R respectively. The correlation betw een the expression of PTEN and the pathogenesis of coronary heart disease w as analyzed. Results The expression of PTENprotein in myocardium in cases w ith coro-nary heart disease w as significantly low er com pared w ith the control group (P<0.05). There w as no sta-tistical difference of the expression of PTEN m RNA betw een experim ental and control group (P>0.05). Conclusion PTEN m ay be involved in the occurrence and developm ent of coronary heart disease.