Author(s): Yang, Taiqun, Dai, Shan, Qin, Cuifang, Huang, Kehan, Chen, Yuting, Pan, Haifeng, Zhang, Sanjun, Zhang, Kun, Xu, Jianhua, State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Collaborative Innovation Center of Extreme Optics, Shanxi University
Pages: 867-871
Year: 2016 Issue:  4
Journal: Chinese Journal of Organic Chemistry
Keyword:  homocysteine; poly methyl vinyl ether-alt-maleic acid; fluorescent sensor; silver nanoclusters;
Abstract: We report selective detection of homocysteine(Hcy) through luminescent poly methyl vinyl ether-alt-maleic acid(PMVEM) silver nanoclusters(Ag NCs), which were synthesized using PMVEM as scaffold. The as-developed PMVEM-Ag NCs have two emission peaks at 460 and 540 nm. After Hcy was added, the thiol moiety of Hcy can efficiently coordinate on Ag NCs, resulting in luminescence quenching of the 460 and 540 nm peaks. However, the ratio of these two emission peak was linearly correlated with the Hcy concentration from 5 to 100 μmol/L. The detection limits was 1 μmol/L. The detection of Hcy used the ratio of the two emission peaks, which permit selective detection of Hcy and quantitive determination of Hcy levels.