Clinical study on immunoglobulin combined with pidotimod and ribavirin in treatment of children with severe hand-foot-mouth disease
Author(s): FU Hua, XING Jian-xia, LI Yan-jing, MA Yan-ling, WEN Bo, Department of Pediatrics, The Third Hospital of Qinhuangdao, Fever Clinics, The Third Hospital of Qinhuangdao, The Second Department of Respiratory, The Third Hospital of Qinhuangdao, Department of Medicine, Qinhuangdao Health School
Pages: 611-614
Year: 2016 Issue: 5
Journal: World Phytomedicines
Keyword: Human Immunoglobulin(pH4) for iv injection; Pidotimod Oral Solution; Ribavirin Injection; hand-foot-mouth disease;
Abstract: Objective To investigate the curative effect of immunoglobulin combined with pidotimod and ribavirin in treatment of children with severe hand-foot-mouth disease. Methods Children(100 cases) with severe hand-foot-mouth disease in Qinhuangdao Third Hospital from January 2013 to January 2015 were enrolled in this study. According to different treatment plans the patients were divided into control(50 cases) and treatment(50 cases) groups. Patients in the control group were iv administered with Ribavirin Injection, 10 mg/kg, once daily, and were po administered with Pidotimod Oral Solution, 400 mg/time, once daily. Patients in the treatment group were iv administered with Human Immunoglobulin(p H4) for iv injection on the basis of control group, 1.5 m L/kg, once daily. The patients in two groups were treated for 7 d. The clinical efficacy in two groups was evaluated, the subsided time of fever, oral ulcer, skin rash, recovery time, changes of CK and CRP levels were compared in two groups before and after treatment. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 100.00%, respectively, and there were differences between two groups(P < 0.01). After treatment, the subsided time of fever, oral ulcer, skin rash, and recovery time in treatment group were lower than those in the control group, the difference was statistically significant(P < 0.01). The CK and CRP levels in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). difference was statistically significant in the same group(P < 0.01), and there was no difference between two groups. Conclusion Immunoglobulin combined with pidotimod and ribavirin in treatment of children with severe hand-foot-mouth disease has good curative effect, which has a certain clinical application value.
Pages: 611-614
Year: 2016 Issue: 5
Journal: World Phytomedicines
Keyword: Human Immunoglobulin(pH4) for iv injection; Pidotimod Oral Solution; Ribavirin Injection; hand-foot-mouth disease;
Abstract: Objective To investigate the curative effect of immunoglobulin combined with pidotimod and ribavirin in treatment of children with severe hand-foot-mouth disease. Methods Children(100 cases) with severe hand-foot-mouth disease in Qinhuangdao Third Hospital from January 2013 to January 2015 were enrolled in this study. According to different treatment plans the patients were divided into control(50 cases) and treatment(50 cases) groups. Patients in the control group were iv administered with Ribavirin Injection, 10 mg/kg, once daily, and were po administered with Pidotimod Oral Solution, 400 mg/time, once daily. Patients in the treatment group were iv administered with Human Immunoglobulin(p H4) for iv injection on the basis of control group, 1.5 m L/kg, once daily. The patients in two groups were treated for 7 d. The clinical efficacy in two groups was evaluated, the subsided time of fever, oral ulcer, skin rash, recovery time, changes of CK and CRP levels were compared in two groups before and after treatment. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 100.00%, respectively, and there were differences between two groups(P < 0.01). After treatment, the subsided time of fever, oral ulcer, skin rash, and recovery time in treatment group were lower than those in the control group, the difference was statistically significant(P < 0.01). The CK and CRP levels in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). difference was statistically significant in the same group(P < 0.01), and there was no difference between two groups. Conclusion Immunoglobulin combined with pidotimod and ribavirin in treatment of children with severe hand-foot-mouth disease has good curative effect, which has a certain clinical application value.
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