Author(s): Sun Xiaoping, Li Zhuoqiong, Chang Xiujuan, Li Wei, Zhou Jun, Wang Zhenzhong, Xiao Wei, Jiangsu Kanion Pharmaceutical, Ltd., State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process
Pages: 489-492
Year: 2016 Issue:  3
Journal: World Science and Technology-Modernization of Traditional Chinese Medicine
Keyword:  Qibaipingfei granules; antitussive; expectorant; antiasthmatic;
Abstract: This study was aimed to investigate the antitussive, expectorant and antiasthmatic effects of Qibaipingfei(QBPF) granules. Cough model was induced by ammonia. Asthma model was induced by histamine and acetylcholine in guinea pig. And the expectorant experiment was determined by phenol sulphonphthalein excretion in mice to evaluate the antitussive, expectorant and antiasthmatic effects of drug. Compared with the model group, the number of cough was significantly decreased in each dose of QBPF groups. And there was lower trend in latency of cough with no significant differences. The excretory amounts of phenol sulphonphthalein were increased by all doses of QBPF groups. The latency of asthma was extended in all doses of QBPF groups and fell time was increased by high dose of QBPF group. It was concluded that QBPF granules has significant antitussive, expectorant and antiasthmatic effect.