The Effect and Mechanism of Berberine on Preventing Atherosclerosis
Author(s): TANG Li-li, ZHANG Yue, LI Hui, DONG Jiao-jiao, ZHANG Yan-qing, School of Biology and Basic Medical Sciences, Soochow University
Pages: 5637-5640
Year: 2015 Issue: 29
Journal: Biomagnetism
Keyword: Berberine; Atherosclerosis; Inflammatory factor;
Abstract: Objective: To investigate the effect of berberine on lipid metabolism and atherosclerosis in hyperlipidemic rabbits as well as the protetil mechanism. Methods: Thirty two rabbits were randomly divided into 4 groups(8 rabbits every group8/group): normal group, untreated cholesterol-fed group, berberine treated group and atorvastatin group. The normal group was fed with normal food while the other groups were fed with high-cholesterol food. The serum total cholesterol(TC), triglycerides(TG), low density lipoprotein-cholesterol(LDL-C), high density lipoprotein-cholesterol(HDL-C) and ox-LDL, MCP-1, MMP-9 levels in sera of model rabbits before and after administration with berberine by gavage were determined. The aorta was dissected and excised to observe the occurrence of plaque rupture and thrombosis. The aortic arteries were observed for pathomorphology by HE staining. Results: As compared to control group, the serum TC, TG, LDL-C levels of models rabbis increased significantly(P<0.01), while the endangium was thickened. And the serum TC,TG, LDL-C and inflammation mediators levels of berberine group and atorvastatin group was decreased compared with high cholesterol group(P<0.01). The I/M of artery in high cholesterol group was higher than in the berberine group or atorvastatin group. There was no significant difference between berberine group and atorvastatin group. Conclusions: Berberine obviously reduced the blood lipid levels and aortic atherosclerosis, and decrease the formation of plague as well as the inflammation mediators levels.
Pages: 5637-5640
Year: 2015 Issue: 29
Journal: Biomagnetism
Keyword: Berberine; Atherosclerosis; Inflammatory factor;
Abstract: Objective: To investigate the effect of berberine on lipid metabolism and atherosclerosis in hyperlipidemic rabbits as well as the protetil mechanism. Methods: Thirty two rabbits were randomly divided into 4 groups(8 rabbits every group8/group): normal group, untreated cholesterol-fed group, berberine treated group and atorvastatin group. The normal group was fed with normal food while the other groups were fed with high-cholesterol food. The serum total cholesterol(TC), triglycerides(TG), low density lipoprotein-cholesterol(LDL-C), high density lipoprotein-cholesterol(HDL-C) and ox-LDL, MCP-1, MMP-9 levels in sera of model rabbits before and after administration with berberine by gavage were determined. The aorta was dissected and excised to observe the occurrence of plaque rupture and thrombosis. The aortic arteries were observed for pathomorphology by HE staining. Results: As compared to control group, the serum TC, TG, LDL-C levels of models rabbis increased significantly(P<0.01), while the endangium was thickened. And the serum TC,TG, LDL-C and inflammation mediators levels of berberine group and atorvastatin group was decreased compared with high cholesterol group(P<0.01). The I/M of artery in high cholesterol group was higher than in the berberine group or atorvastatin group. There was no significant difference between berberine group and atorvastatin group. Conclusions: Berberine obviously reduced the blood lipid levels and aortic atherosclerosis, and decrease the formation of plague as well as the inflammation mediators levels.
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