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Effect of Buyang Huanwu Decoction on Hippocampus Neurons and 5-HT Contents in Rats with Transient Ischemia Reperfusion Injury
Pages: 62-64
Year: Issue:  5
Journal: Journal of Liaoning College of Traditional Chinese Medicine

Keyword:  Buyang Huanwu Decoctionthe transient ischemic reperfusionrat;
Abstract: Objective:To explore the effects of Buyang Huanwu Decoction on the transient cerebral ischemia reperfusion injury. Methods:Wistar rats were selected,and the method of the transient ischemia reperfusion was established in rats by bilateral carotid artery clamping. It is to determine the Stroke Index score and to see the morphologic changes of neurons in hippocampus. The expression of 5-HT in hippocampus is determined by enzyme linked immunosorbent assay(ELISA). Results:8 d after operation,the treatment group compared with the model group could significantly decline on the stroke index(P<0.01). Compared with the treatment group after 8 d,postoperative 1 d the Stroke Index has improved significantly(P<0.05). Compared with the normal group,the model group rats hippocampus 5-HT content decreased obviously(P<0.01).Compared with the model group,5-HT content of the treatment group rats hippocampus significantly increased(P<0.01). Conclusions:Buyang Huanwu Decoction can effectively improve the transient ischemic reperfusion injury.
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