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Protective Effect of Pine Polyphenols and Its Transformation by Aspergillus Carbonarius on γ-radiation Induced Immune Injuries in Mice
Pages: 84-89
Year: Issue:  2
Journal: Space Medicine & Medical Engineering

Keyword:  antioxidantγ-radiationaspergillus carbonariuspine polyphenols;
Abstract: Objective To reveal the protective mechanism of the immune injury in mice induced by γ-radiation of pine polyphenols( PPs) and its transformation by Aspergillus carbonarius( ACPP). Methods ACPP and PPs served as the research subjects. The scavenging activities of ABTS,DPPH,superoxide anion and hydroxyl free radicals were assayed and compared. The mice model induced by60 Co γ-radiation was adopted and the spleen B lymphocyte transformation proliferation,peripheral blood and biochemical status was determined by MTT and biochemical methods. The expression levels of Bax,Bcl-2 and Caspase-3 were determined by Western blotting. Results ACPP demonstrated a stronger antioxidant activity. The radioprotective effect of ACPP and PPs was realized by improving the content of antioxidants,promoting enzymatic( SOD,CAT and GSHPx) and non-enzymatic( GSH) antioxidants,spleen B lymphocyte transformation proliferation and phagocytic index,reducing the lipid peroxidation and the expression levels of Bax and Caspase-3,and increasing the Bcl-2 in the spleen tissue. The radioprotective effect of ACPP was better than PPs. Conclusion ACPP is of antioxidant activity and radioprotective effect,and so it is a reliable basic material in resistance to ionizing radiations.
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