Role of SDF-1/CXCR4 Axis in Mesenchymal Stem Cell Homing Mechanisms
Author(s): WANG Zhi-xia, MO Bi-wen, NIU Kun-ting, WEI Jiang-hong, RAO Li-zong, Department of Respiratory Medicine, Affiliated Hospital of Guilin Medical College
Pages: 1995-1997
Year: 2016 Issue: 10
Journal: Biomagnetism
Keyword: Mesenchymal stem cells; Stromal cell-derived factor 1; C-X-C chemokine receptor 4; Homing;
Abstract: Mesenchymal stem cells are pluripotent adult stem cells, which have ability to secrete trophic factors and to modulate inflammatory responses. Although the roles of mesenchymal stem cells in tissue repair, remodeling and immunomodulatory have been accepted by clinic, however, the mechanism of MSCs Chemotaxis and homing remains unclear. SDF-1/CXCR4 axis plays a vital role in mediating the differentiation, migration and homing of MSCs. If they could be done an in-depth inquiry, to clarify the mechanisms of homing, it will contribute to the application of Mesenchymal stem cells in clinic.
Pages: 1995-1997
Year: 2016 Issue: 10
Journal: Biomagnetism
Keyword: Mesenchymal stem cells; Stromal cell-derived factor 1; C-X-C chemokine receptor 4; Homing;
Abstract: Mesenchymal stem cells are pluripotent adult stem cells, which have ability to secrete trophic factors and to modulate inflammatory responses. Although the roles of mesenchymal stem cells in tissue repair, remodeling and immunomodulatory have been accepted by clinic, however, the mechanism of MSCs Chemotaxis and homing remains unclear. SDF-1/CXCR4 axis plays a vital role in mediating the differentiation, migration and homing of MSCs. If they could be done an in-depth inquiry, to clarify the mechanisms of homing, it will contribute to the application of Mesenchymal stem cells in clinic.
Related Articles