Evaluation of liver reserve function using whole-liver volume computed tomography perfusion imaging in patients with hepatitis B and liver cirrhosis
Author(s): Ma Zhenbo, Xie Yuanzhong
Pages: 115-119
Year: 2016 Issue: 2
Journal: Anatomy and Clinics
Keyword: Hepatitis B; Liver cirrhosis; Tomography; X-ray computed; Perfusion;
Abstract: Objective To investigate the value of hepatitis B, hepatitis B cirrhosis of the liver of the left lobe, right lobe and the whole liver perfusion parameters in whole liver volume CT perfusion imaging (VCTP) for evaluating liver reserve function. Methods All cases are from Taian Central Hospital from November 2012 to February 2014. The objects brought into our prospective research underwent whole liver volume CT perfusion imaging ( VCTP) were composed of 26 patients with hepatitis B, 24 patients that suffered from hepatitis B cirrhosis in compensatory period and 22 patients with hepatitis B cirrhosis in decompensatory period, who were confirmed by clinical and other imaging examinations, and 30 cases in the control group. A total of five perfusion indexes that consisted of blood flow (BF), blood volume (BV), hepatic artery perfusion (ALP), portal vein perfusion (PVP) and hepatic artery perfusion index ( HPI) were analyzed. The liver CT perfusion parameters in different groups were compared by one-way ANOVA analysis of variance. The results would be statistically significant when the value of P was less than 0. 05. Results The statistical analysis for parameter of perfusion of BF, BV, ALP, PVP and HPI in liver right lobe among control, hepatisis B, hepatitis B cirrhosis in compensatory period, and hepatitis B cirrhosis in decompensatory period groups was used one-way ANOVA analysis of variance. As the degree of liver pathological change was aggravated, the values of BF, BV and PVP of liver right lobe, liver left lobe and whole liver gradually decreased, but the value of HPI gradually increased, and the differences were statistically significant(all P values < 0. 05). The evaluations on liver function by liver right lobe, liver left lobe and whole liver perfusion parameters were consistent, and there was no significant difference between the perfusion parameters of liver left and right lobe. The perfusion parameter of ALP had no statistical significance(all P values > 0. 05). Conclusions The whole liver VCTP can reflect the hemodynamic changes of hepatitis B and hepatitis B cirrhosis. The perfusion parameters of BF, BV and PVP of liver right lobe and left lobe gradually decrease, along with the aggravation of the degree of liver pathological change. The evaluations on liver function by liver right lobe, liver left lobe and whole liver perfusion parameters are consistent.
Pages: 115-119
Year: 2016 Issue: 2
Journal: Anatomy and Clinics
Keyword: Hepatitis B; Liver cirrhosis; Tomography; X-ray computed; Perfusion;
Abstract: Objective To investigate the value of hepatitis B, hepatitis B cirrhosis of the liver of the left lobe, right lobe and the whole liver perfusion parameters in whole liver volume CT perfusion imaging (VCTP) for evaluating liver reserve function. Methods All cases are from Taian Central Hospital from November 2012 to February 2014. The objects brought into our prospective research underwent whole liver volume CT perfusion imaging ( VCTP) were composed of 26 patients with hepatitis B, 24 patients that suffered from hepatitis B cirrhosis in compensatory period and 22 patients with hepatitis B cirrhosis in decompensatory period, who were confirmed by clinical and other imaging examinations, and 30 cases in the control group. A total of five perfusion indexes that consisted of blood flow (BF), blood volume (BV), hepatic artery perfusion (ALP), portal vein perfusion (PVP) and hepatic artery perfusion index ( HPI) were analyzed. The liver CT perfusion parameters in different groups were compared by one-way ANOVA analysis of variance. The results would be statistically significant when the value of P was less than 0. 05. Results The statistical analysis for parameter of perfusion of BF, BV, ALP, PVP and HPI in liver right lobe among control, hepatisis B, hepatitis B cirrhosis in compensatory period, and hepatitis B cirrhosis in decompensatory period groups was used one-way ANOVA analysis of variance. As the degree of liver pathological change was aggravated, the values of BF, BV and PVP of liver right lobe, liver left lobe and whole liver gradually decreased, but the value of HPI gradually increased, and the differences were statistically significant(all P values < 0. 05). The evaluations on liver function by liver right lobe, liver left lobe and whole liver perfusion parameters were consistent, and there was no significant difference between the perfusion parameters of liver left and right lobe. The perfusion parameter of ALP had no statistical significance(all P values > 0. 05). Conclusions The whole liver VCTP can reflect the hemodynamic changes of hepatitis B and hepatitis B cirrhosis. The perfusion parameters of BF, BV and PVP of liver right lobe and left lobe gradually decrease, along with the aggravation of the degree of liver pathological change. The evaluations on liver function by liver right lobe, liver left lobe and whole liver perfusion parameters are consistent.
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