Author(s): WANG Jing, CHENG Xiao-rui, ZHOU Wen-xia, WANG Shu-mei, Guangdong Pharmaceutical University, Department of Traditional Medicine and Neuroimmunopharmacology, State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences
Pages: 191-198
Year: 2016 Issue:  2
Journal: International Journal of Pharmaceutical Research
Keyword:  Alzheimer′s disease; vesicle glutamate transporter; β-amyloid protein; neurofibrillary tangles; excitoxicity;
Abstract: Vesicle glutamate transporter(VGLUT) specifically transfers glutamate into synaptic vesicle,determines the amount of glutamate released into the synaptic cleft,then regulates the efficiency of glutamatergic synaptic transmission. VGLUT plays an important role in the pathogenesis of Alzheimer′s diseases(AD). VGLUT is significantly decreased in the brain of AD patients and closely correlated with cognitive dysfunction,beta- amyloid aggregation,tau protein phosphorylation and glutamate excitoxicity.VGLUT,the possible specific biomarker of glutamatergic neuron,has been considered a potential drug target in the treatment of AD and biomarkers in the early diagnosis of AD. There are some advances on chemicals targeting on VGLUT.