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Effects of rosuvastatin on proliferation and apoptosis of human glioma U251 cells
Author(s): 
Pages: 415-418
Year: Issue:  4
Journal: World Phytomedicines

Keyword:  rosuvastatinhuman glioma U251 cellsproliferationapoptosis;
Abstract: Objective To explore the influence of rosuvastatin on proliferation and apoptosis of human glioma U251 cells. Methods Human glioma U251 cells were cultured in vitro, and treated by rosuvastatin with the concentrations of 5, 10, and 20 μmol/L. After cultivation for 24, 48, 72, and 96 h, proliferation activities and cell cycle distribution were determined by MTT colorimetric assay and flow cytometer. Results Compared with the control group, A570 nm values of rosuvastatin groups had obvious changes, and were significantly decreased after being treated for 96 h(P < 0.01). Compared with the control group, cells in G0/G1 phase were increased, but those in S and G2/M phases were decreased after being treated for 96 h by rosuvastatin, which had dose-effect dependence. Apoptosis of human glioma U251 cells were induced by rosuvastatin with various concentrations treated for 48 — 72 h. With the increase of the concentrations and action time of rosuvastatin, the apoptotic peaks were more obvious, and showed concentration-effect dependent and time-concentration dependent. Conclusion Rosuvastatin can inhibit the proliferation of human glioma U25 l cells, and induced their apoptosis.
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