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Clinical observation of albumins combined with Salivae Miltiorrhizae, Liguspyragine Hydrochloride and Glucose Injection in treatment of acute progressing cerebral infarction
Author(s): 
Pages: 454-457
Year: Issue:  4
Journal: World Phytomedicines

Keyword:  Human AlbuminsSalivae MiltiorrhizaeLiguspyragine Hydrochloride and Glucose Injectionacute progressing cerebral infarctionNIHSS scoreBarthel indexhemorheological indexes;
Abstract: Objective To observe the clinical effect of low-dose Human Albumins combined with Salivae Miltiorrhizae, Liguspyragine Hydrochloride and Glucose Injection(SGI) in treatment of acute progressing cerebral infarction. Methods Patients(90 cases) with acute progressing cerebral infarction in Tianjin Hospital from August 2013 to June 2015 were randomly divided into control and treatment groups, and each group had 45 cases. All patient in two groups were treated with the basic therapy. Patients in the control group were iv administered with SGI, 100 m L/time, once daily. Patients in the treatment group were iv administered with 20% Human Albumins on the basis of the control group, 50 m L/time, once daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and NIHSS score, Barthel index, and hemorheological indexes before and after treatment in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 57.78% and 84.44%, respectively, and there were differences between two groups(P < 0.05). After treatment, NIHSS scores in two groups were significantly decreased, but Barthel indexes were significantly increased, and the differences were statistically significant in the same group(P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the whole blood viscosity, plasma viscosity, hematocrit, and fibrinogen were significantly decreased, and the differences were statistically significant in the same group(P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Low-dose Human Albumins combined with SGI has clinical curative effect in treatment of acute progressing cerebral infarction, and can significantly reduce NIHSS scores, increase Barthel indexes, obviously improve hemorheological indexes, which has a certain clinical application value.
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