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Clinical observation of Compound Danshen Dripping Pills combined with levamlodipine besylate in treatment of elderly isolated systolic hypertension
Author(s): 
Pages: 458-462
Year: Issue:  4
Journal: World Phytomedicines

Keyword:  Compound Danshen Dripping PillsLevamlodiping Besylate Tabletsisolated systolic hypertension;
Abstract: Objective To discuss the clinical effect of Compound Danshen Dripping Pills combined with Levamlodiping Besylate Tablets in treatment of elderly isolated systolic hypertension. Methods Patients(80 cases) with isolated systolic hypertension in Beijing Miyun District Guoyuan Community Health Service Center from August 2014 to August 2015 were divided into control and treatment groups according to the random number table, and each group had 40 cases. All patients in two groups were given the conventional treatment. The patients in the control group were po administered with Levamlodiping Besylate Tablets, 5 mg/time, once daily. The patients in the treatment group were po administered with Compound Danshen Dripping Pills on the basis of control group, 40 pills/time, twice daily. The patients in two groups were treated for 3 months. After treatment, the efficacies were evaluated, and the blood pressure indicators, blood lipid changes, the circadian rhythm of blood pressure changes, inner diameter of blood and expansion in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 72.50% and 92.50%, respectively, and there were differences between two groups(P < 0.05). After treatment, 24 h diastolic blood pressure, 24 h systolic blood pressure, daytime blood pressure load, and the value of nighttime blood pressure load in two groups were significantly decreased, with significant difference between two groups(P < 0.05). After treatment, the levels of TC and LDL-C in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the observational indexes in the treatment group were significantly decreased than those in the control group, with significant difference between two groups(P < 0.05). Circadian rhythms of diastolic and systolic blood pressure changes in the control and treatment groups were 30.00%, 35.00% and 80.00%, 87.50%, respectively, and there were differences between two groups(P < 0.05). After treatment, blood expansions in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). After treatment, blood expansions in two groups were significantly decreased, with significant difference between two groups(P < 0.05). Conclusion Compound Danshen Dripping Pills combined with Levamlodiping Besylate Tablets has clinical curative effect in the treatment of elderly isolated systolic hypertension, can raise blood pressure circadian rhythm changes efficiently, is less adverse reactions, which has a certain clinical application value.
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