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Clinical study on Shanlameiye Granules with ribavirin in treatment of pediatric acute upper respiratory infection
Author(s): 
Pages: 435-439
Year: Issue:  4
Journal: World Phytomedicines

Keyword:  Shanlameiye GranulesRibavirin Injectionpediatric acute upper respiratory infectionimmunoglobulin;
Abstract: Objective To investigate the clinical effect and safety of Shanlameiye Granules with Ribavirin Injection in treatment of pediatric acute upper respiratory infection. Methods Children(128 cases) with acute upper respiratory infection in Shanghai the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University from January 2014 to January 2015 were randomly divided into control and treatment groups, and each group had 64 cases. Patients in the control group were iv administered with Ribavirin Injection, 10 mg/kg, once daily, 7 d as one course. Patients in the treatment group were po administered with Shanlameiye Granules on the basis of control group, 1 bag/time, three time daily, 7 d as one course. After treatment, the clinical efficacies were evaluated, and the improvement time of clinical symptoms, hospital stay time, blood routine, immune function indexes, and adverse reaction in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 89.06% and 98.44%, respectively, and there was difference between two groups(P < 0.05). After treatment, the time of hospitalization and the clinical symptom improvement including normal temperature, cough disappeared, pharyngalgia and hyperemia, infection of tonsil, and runny nose and nasal congestion in the treatment group were significantly lower than those in the control group, and there were differences between two groups(P < 0.05). After treatment, WBC in two groups were significantly increased, but lymphocyte ratio in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). After treatment for 3 d, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, IgA, IgE, IgM, and ADA in two groups were significantly decreased, but IgG in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). The incidence of adverse reactions in control and treatment groups were 18.75% and 6.25%, respectively, and there was difference between two groups(P < 0.05). Conclusion Shanlameiye Granules with Ribavirin Injection has clinical curative effect in treatment of pediatric acute upper respiratory infection, and can rapidly improve the clinical symptoms of patients, can shorten the time of hospitalization, less adverse reactions, which has a certain clinical application value.
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