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Improvement of salvianolic acids on hemorheology of diabetic rats and its mechanism
Author(s): 
Pages: 419-422
Year: Issue:  4
Journal: World Phytomedicines

Keyword:  salvianolic acidshemorheologysurface biological characteristics of red cell membraneimprovement;
Abstract: Objective To study the improvement of salvianolic acids on hemorheology of diabetic rats and to explore its mechanism. Methods SD rats were randomly divided into control and model groups. And there were 10 rats in the control group, and 30 rats in the model group. Diabetes model were induced. Diabetic rats were randomly divided into model group and salvianolic acids(1.79 and 5.26 mg) groups, and each group had 10 rats. Rats in salvianolic acids groups were ip administered with Depsides Salts from Salvia miltiorrhiza in Lyophilizied Powder for injection 1.79 and 5.26 mg(magnesium acetate as index), and those in control and model groups were ip administered with the same volume of normal saline. The volume was 2.76 m L/kg, the treatment were carried out once daily, and lasted for 14 d. The indexes of hemorheology and surface characteristics of erythrocyte membrane were determined. Results Compared with the model group, the whole blood viscosity 3, whole blood viscosity 50, erythrocyte electrophoretic time, and ESR equation K values in salvianolic acids(1.79 and 5.26 mg/kg) groups were significantly decreased(P < 0.05, 0.01). Compared with the model group, the contents of sialic acid in salvianolic acids(1.79 and 5.26 mg/kg) groups were significantly increased(P < 0.05), and Na+-K+-ATP enzyme activities and SOD levels in salvianolic acids(5.26 mg/kg) group were significantly increased(P < 0.05). Conclusion Salvianolic acids can increase sialic acid contents of red cell surface, enhance antioxidant capacity of erythrocyte membrane, and improve hemorheology characteristics of diabetic rats.
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