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Clinical study on Puterarin Injection combined with fasudil hydrochloride in treatment of ischemic cerebral infarction
Author(s): 
Pages: 445-448
Year: Issue:  4
Journal: World Phytomedicines

Keyword:  Puterarin InjectionFasudil Hydrochloride Injectionischemic cerebral infarctionNIHSS scores;
Abstract: Objective To investigate the clinical effect of Puterarin Injection combined with fasudil hydrochloride in treatment of ischemic cerebral infarction. Methods Patients(84 cases) with ischemic cerebral infarction in Huashan Township Health Center of Huadu District in Guangzhou from June 2014 to June 2015 were enrolled in this study. According to the different treatment plans, patients were divided into control group(42 cases) and treatment group(42 cases). The patients in the control group were iv administered with Fasudil Hydrochloride Injection, 60 mg added into normal saline 250 m L, once daily. The patients in the treatment group were iv administered with Puterarin Injection on the basis of control group, 400 mg added into normal saline 250 m L, once daily. The patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the changes of ESR, HCT, FIB, RF, HS, NIHSS scores, and ET-1 in two groups before and after treatment were compared. The adverse reactions in two groups were compared. Results After treatment, the efficacies in the control and treatment groups were 80.95 and 95.24%, respectively, and there were differences between two groups(P < 0.05). After treatment, ESR, HCT, FIB, RF, HS, NIHSS scores, and ET-1 in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). The incidence of adverse reactions in the control and treatment groups were 9.52% and 7.14%, respectively, and there was no difference between two groups. Conclusion Puterarin Injection combined with fasudil hydrochloride has clinical curative effect in treatment of ischemic cerebral infarction, and can significantly improve hemorheology status, and can significantly reduce the expression of ET-1, which has a certain clinical application value.
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