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Clinical observation of thioctic acid combined with Isophane Protamine Biosynthetic Human Insulin Injection in treatment of type 2 diabetes
Author(s): 
Pages: 463-466
Year: Issue:  4
Journal: World Phytomedicines

Keyword:  Thioctic Acid InjectionIsophane Protamine Biosynthetic Human Insulin Injectiontype 2 diabetesFBG2 h PBGHbA1c;
Abstract: Objective To investigate the clinical effect of thioctic acid combined with Isophane Protamine Biosynthetic Human Insulin Injection in treatment of type 2 diabetes. Methods Patients(300 cases) with type 2 diabetes in Longbai Community Health Service Center of Minhang District in Shanghai from August 2012 to December 2015 were randomly divided into control and treatment groups, and each group had 150 cases. The patients in the control group were sc administered with Isophane Protamine Biosynthetic Human Insulin Injection, 0.4 U/kg for the first time, twice daily, before breakfast and dinner. The dosage was adjusted according to the treatment status of patients. The patients in two groups were treated for 1 month. The dosages of insulin in two groups were observed, and the changes of FBG, 2 h PBG, Hb A1 c, and scores of quality life in two groups before and after treatment were compared. Results After treatment, the dosage of insulin in treatment group before breakfast, dinner and throughout the day were significantly lower than those in the control group, and there were differences between two groups(P < 0.05). After treatment, FBG, 2 h PBG, and Hb A1 c in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the scores of stress evaluation, social relations, nutritional status, and exercising state were significantly increased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Thioctic acid combined with Isophane Protamine Biosynthetic Human Insulin Injection has clinical curative effect in treatment of type 2 diabetes, and can reduce the dosage of insulin injection, and can better control FBG and 2 h PBG, also can improve the life quality of patients, which has a certain clinical application value.
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