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Clinical observation of extracts injection from rabbit skin inflamed by vaccinia virus combined with mecobalamine in treatment of chemotherapy-induced peripheral neuropathy
Author(s): 
Pages: 483-487
Year: Issue:  4
Journal: World Phytomedicines

Keyword:  extracts injection from rabbit skin inflamed by vaccinia virusMecobalamin Injectionchemotherapy-induced peripheral neuropathy;
Abstract: Objective To investigate the clinical efficacy of extracts injection from rabbit skin inflamed by vaccinia virus combined with mecobalamine in treatment of chemotherapy-induced peripheral neuropathy. Methods Patients(146 cases) with peripheral neuropathy in Changshu No.1 People’s Hospital from February 2013 to March 2015 were divided into control and treatment groups, and each group had 73 cases. The patients in the control group were im administered with Mecobalamin Injection, 0.5 mg/time, once daily. The patients in the treatment group were iv administered with rabbit skin inflamed by vaccinia virus, 7.2 U added into 250 m L normal saline, once daily. The patients in two groups were treated for two weeks. The clinical efficacies in two groups were observed, and the changes of nerve conduction velocity and VAS scores were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 58.90% and 89.04%, respectively, and there was difference between groups(P < 0.05). After one week of treatment, sensory nerve conduction velocity and motor nerve conduction velocity in two groups were both improved, and there were differences between two groups(P < 0.05). After two weeks of treatment, sensory nerve conduction velocity and motor nerve conduction velocity were better than those before treatment, and there were differences between two groups(P < 0.05). After one week of treatment, VAS scores in two groups were lower than those before treatment, and there were differences between two groups(P < 0.05). After two weeks of treatment, VAS scores in two groups were lower than those before treatment, and there were differences between two groups(P < 0.05). Conclusion Extracts injection from rabbit skin inflamed by vaccinia virus combined with mecobalamine has clinical curative effect in treatment of chemotherapy-induced peripheral neuropathy, and can significantly improve nerve conduction velocity and improve the quality of life with high safety, which has a certain clinical application value.
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