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Clinical study on levofloxacin combined with triple therapy in treatment of Helicobacter pylori associated gastric ulcer
Author(s): 
Pages: 533-536
Year: Issue:  4
Journal: World Phytomedicines

Keyword:  Levofloxacin Lactate Tabletstriple therapyHelicobacter pylori associated gastric ulcerinflammatory factors;
Abstract: Objective To study the efficacy of Levofloxacin Lactate Tablets combined with triple therapy in treatment of Helicobacter pylori associated gastric ulcer. Methods Patients(134 cases) with H. pylori associated gastric ulcer in The People’s Hospital of Liaoning Province from June 2014 to Jun 2015 were randomly divided into control(n = 67) and treatment(n = 67) groups. Patients in the control group were treated with triple therapy, and the patients in the treatment group were po administered with Levofloxacin Lactate Tablets from 6th day on the basis of the control group, 200 mg/time, once daily. The patients in two groups were treated for 10 d. After treatment, the efficacy and H. pylori eradication rate were evaluated, and inflammatory factors in serum and incidence rate of adverse reaction in two groups were compared. Results After treatment, H. pylori eradication rate in the treatment group(83.6%) was higher than that(52.2%) of the control group, and the efficacies in the control and treatment groups were 79.1% and 94.0%, respectively, and there were differences between two groups(P < 0.05). After treatment, levels of IL-6 and IL-17 in serum in two groups were significantly decreased, but that of IFN-γ were significantly increased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). There was no difference of incidence rate of adverse reaction between two groups. Conclusions Levofloxacin Lactate Tablets combined with triple therapy has clinical curative effect in treatment of H. pylori associated gastric ulcer, has better efficacy than the single triple therapy, and can significantly reduce the inflammatory reaction with less increase in adverse reactions, which has a certain clinical application value.
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