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Clinical observation of Remifemin Tablets combined with estradiol valerate and progesterone in treatment of perimenopausal syndrome
Author(s): 
Pages: 508-512
Year: Issue:  4
Journal: World Phytomedicines

Keyword:  Remifemin TabletsEstradiol Valerate TabletsProgesterone Capsulesperimenopausal syndrome;
Abstract: Objective To observe the clinical effect of Remifemin Tablets combined with Estradiol Valerate Tablets and Progesterone Capsules in treatment of perimenopausal syndrome. Methods Patients(88 cases) with perimenopausal syndrome in Tunchang People’s Hospital from June 2013 to June 2015 were enrolled in this study. According to the different treatment plan, patients were divided into control and treatment groups, and each group had 44 cases. The patients in the control group were po administered with Estradiol Valerate Tablets, 1 mg/time, once daily. After treatment for one month, the patients were po administered with Progesterone Capsules, 2 grains/times, once daily. The patients in the treatment group were po administered with Remifemin Tablets on the basis of control group, 1 tablet/time, twice daily. The patients in two groups were treated for three months. After treatment, clinical efficacy was evaluated, and KMI scores, vaginal atrophy symptom scores, and levels of FSH and E2 in two groups were compared before and after treatment. Results After treatment, the efficacies in the control and treatment groups were 86.36% and 93.73%, respectively, and there was significant difference between groups(P < 0.05). After treatment, the scores of hot flushes and sweating, paresthesia, insomnia, depression, itchy skin, and joint pain, and total KMI score in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the scores of colpoxerosis, itchy vaginal, intercourse pain, and vaginal atrophy symptom in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the FSH in two groups was significantly decreased, but the E2 in two groups were significantly increased, and the difference was statistically significant in the same group(P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Remifemin Tablets combined with Estradiol Valerate Tablets and Progesterone Capsules has clinical curative effect in the treatment of perimenopausal syndrome, and can improve the levels of FSH and E2 in patients, and less adverse reactions, which has a certain clinical application value.
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