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Clinical observation of Gonghuan Yangxue Granules combined with mifepristone in treatment of dysfunctional uterine bleeding in perimenopausal period
Author(s): 
Pages: 513-516
Year: Issue:  4
Journal: World Phytomedicines

Keyword:  Gonghuan Yangxue GranulesMifepristone Tabletsperimenopausal perioddysfunctional uterine bleeding;
Abstract: Objective To investigate the clinical efficacy of Gonghuan Yangxue Granules combined with mifepristone in treatment of dysfunctional uterine bleeding in perimenopausal period. Methods Patients(74 cases) with dysfunctional uterine bleeding in perimenopausal period in Hebei Provincial Cixian People’s Hospital from March 2013 to March 2015 were randomly divided into control and treatment groups. Each group had 37 cases. The patients in the control group were po administered with Mifepristone Tablets, 0.5 — 1 tablet/time, twice daily, and the total dose reached almost three tablets after taking for 2 — 3 d. After taking medicine, the patients should be fasted at least 2 h. The patients in the treatment group were po administered with Gonghuan Yangxue Granules on the basis of the control group, 1 — 2 bags/time, twice daily. The patients in two groups were treated for 21 d. Then the patients were stopped taking medicine for 7 d. On the eighth day, the patients were given another course. The patients in two groups were treated for three courses. After treatment, the efficacy was evaluated, and the changes of endometrial thickness, sex hormone indicators estrogen(E2), luteinizing hormone(LH), and follicle-stimulating hormone(FSH) were compared. Results After treatment, the efficacies in the control and treatment groups were 70.3% and 83.8%, respectively, and there were differences between two groups(P < 0.05). After treatment, endometrial thickness in two groups was significantly improved, and the difference was statistically significant in the same group(P < 0.05). And endometrial thickness in the treatment group was significantly better than that in the control group, with significant difference between two groups(P < 0.05). Sex hormone indicators estrogen(E2), luteinizing hormone(LH), and follicle-stimulating hormone(FSH) in the treatment group was significantly better than those before treatment, and there were significant differences between two groups(P < 0.05). The occurrence rates of adverse reaction in the control and treatment groups were 29.7% and 8.1%, and there were differences between two groups(P < 0.05). Conclusion Gonghuan Yangxue Granules combined with mifepristone has clinical curative effect in treatment of dysfunctional uterine bleeding in perimenopausal period, and can significantly improve sex hormone levels with higher security, which has a certain clinical application value.
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