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Clinical study on Piminxiao Capsules combined with compound glycyrrhizin in treatment of chronic urticaria
Author(s): 
Pages: 529-532
Year: Issue:  4
Journal: World Phytomedicines

Keyword:  Piminxiao CapsulesCompound Glycyrrhizin Tabletschronic urticariaDLQI scores;
Abstract: Objective To investigate the clinical efficacy of Piminxiao Capsules combined with Compound Glycyrrhizin Tablets in treatment of chronic urticaria. Methods Patients(78 cases) with chronic urticaria in Department of Dermatology of Sanya Center for Chronic Disease Control from April 2014 to April 2015 were enrolled in this study. According to the difference of treatment plan, the patients were divided into control and treatment groups, and each group had 39 cases. The patients in the control group were po administered with Compound Glycyrrhizin Tablets, 50 mg/time, three times daily. The patients in the treatment group were po administered with Piminxiao Capsules on the basis of control group, 4 grains/time, three times daily. The patients in two groups were treated for 4 weeks. After treatment, the efficacies were evaluated, and symptoms integral, DLQI scores and Ig E in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 79.49% and 94.87%, respectively, and there was difference between two groups(P < 0.05). After treatment, symptoms integral, DLQI scores and Ig E in two groups were significantly decreased, and the differences were statistically significant in the same group(P < 0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the incidence of adverse reactions in the control and treatment groups were 5.13% and 7.69%, respectively, but there was no difference between two groups. The recurernce rate within 6 months in the control and treatment groups were 23.08% and 5.13%, respectively, and there was difference between two groups(P < 0.05). Conclusion Compound Glycyrrhizin Tablets combined with Piminxiao Capsules has clinical curative effect in treatment of chronic urticaria, and can reduce the levels of Ig E, relieve the clinical symptoms of patients, which has a certain clinical application value.
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