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Recent progress in the combination treatment of radiotherapy and PD-1/PD-L1 signaling blockade immunotherapy
Pages: 235-240
Year: Issue:  3
Journal: Chinese Journal of Radiological Medicine and Protection

Keyword:  RadiotherapyPD-1/PD-L1 signal blockadeOncology immunotherapy;
Abstract: Every stage of tumor initiation and development closely relates to immune regulation as tumor cells tend to evade attacks from immune system by employing the programmed death 1 (PD-1)/ programmed death-ligand 1 (PD-L1) interaction.Therefore,targeting the PD-1/PD-L1 pathway has become an attractive approach for cancer immunotherapy.Radiotherapy has long been considered a local tumor treatment modality and it is immune-inhibitory.However,accumulated evidence has shown that radiotherapy might enhance immune function by eliminating the tumor mass and has become a systemic tumor treatment modality.These observations indicate a strong rationale that the radiotherapy and anti-PD1 and anti-PD-L1 immunotherapy may work synergistically to provide a powerful anti-tumor effect.This review discusses current progresses,challenges and perspectives of this novel combination treatment modality.
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