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Dosimetric comparison of three- dimensional conformal radiotherapy and intensity modulated radiotherapy for III-stage non-small cell lung cancer
Author(s): CHEN Ni, LIU Yi-bao, ZHANG Jiu-tang, WEI Qiang-lin, ZHANG li, XU Shi-lei, School of Nuclear Engineering and Geophysics, East China University of Technology, Physical Room, Department of Radiotherapy, Hunan Tumor Hospital
Pages: 198-
203
Year: 2016
Issue:
2
Journal: Chinese Journal of Medical Physics
Keyword: non-small cell lung cancer; three-dimensional conformal radiotherapy; intensity modulated radiotherapy; dosimetry;
Abstract: Objective To provide a reliable treatment basis for selecting the appropriate radiotherapy by comparing the dose differences of target volumes and organs at risk between three-dimensional conformal radiotherapy(3D-CRT) and intensity modulated radiotherapy(IMRT) for III-stage non-small cell lung cancer(NSCLC). Methods Sixteen patients with III-stage NSCLC were selected, and Pinnacle V9.2 treatment planning system was applied to design 3D-CRT and IMRT plans for each patient. The conformity index and homogeneity index of target volumes, and dose distribution of normal tissue were compared. Results The conformity indexes of IMRT and 3D-CRT plans were respectively 0.97 ± 0.02 and 0.91 ± 0.04; the homogeneity indexes of IMRT and 3D-CRT plans were respectively 0.16±0.06 and 0.20±0.14, with statistically significant differences(P<0.05). The dose parameters of organs at risk of IMRT plan were all lower than those of 3D-CRT plan in different degrees, except V5 and V10of lung tissue. Conclusion Compared with 3D-CRT, IMRT for III- stage NSCLC provides significant improvement in conformity and homogeneity, effectively lowers the radiation dose of normal tissue,and lowers the possibility of complication after the radiotherapy.
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