Author(s): SUN Hua, TANG Shuhai, WANG Haoyi, AN Ning, XU Cuiping, ZHAO Dongbo, School of Nursing, Shandong University, Department of Emergency, Shandong Cancer Hospital Affilicated to Shandong University, Department of Anesthesiology, Qilu Hospital of Shandong University, Department of Physiology, School of Medicine, Shandong University, Department of Human Resources, Qianfoshan Hospital Affilicated to Shandong University, Department of Thoracic Surgery, Shandong Cancer Hospital Affilicated to Shandong University
Pages: 19-23
Year: 2016 Issue:  3
Journal: Journal of Shandong University(Health Sciences)
Keyword:  Propofol; Carbachol; Intestinal secretion; Acetylcholine receptor; Short-circuit current;
Abstract: Objective To explore the effect of propofol on carbachol( CCh)-induced chloride secretion in rat ileum mucosa. Methods Cch-induced chloride secretion was measured by Ussing chamber technique. Results Propofol attenuated the CCh-stimulated increase in short-circuit current( Isc) of rat ileum mucosa in a dose-dependent manner( 10- 2-10- 6mol / L). The propofol-evoked inhibitory effect was serosal side-dependent. Furthermore,both TTX,a Na+channel blocker,and hexamethonium bromide,a nicotinic acetylcholine receptor antagonist,had no effect on propofol-evoked inhibitory effect. Conclusion Propofol inhibites CCh-induced intestinal secretion via basolateral m AChR pathway.