Author(s): LIU Lijuan, ZHAO Ruizhi, LU Chuanjian, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine
Pages: 206-210
Year: 2016 Issue:  2
Journal: Journal of Guangzhou University of Traditional Chinese Medicine
Keyword:  optimized Yinxieling Formula/pharmacology; psoriasis/TCD therapy; adjuvant arthritis/immunology; TNF-α; IFN-γ; disease models; animal; rats;
Abstract: Objective To investigate the anti-inflammatory and immuneregulative effect of optimized Yinxieling Formalu(OYF), thus to explore its anti-psoriasis mechanism. Methods Arthritis rat model was induced by Freund’s adjuvant for investigating the influence of OYF on rat articular pathology. Mouse model of increased permeability of abdominal cavity capillary induced by acetic acid was used to evaluate the influence of OYF on the content of mouse peritoneal exudate. Mouse model of liver injury induced by lipopolysaccharide(LPS) was established for the observation of the effect of OYF on the serum content of tumor necrosis factor-alpha(TNF-α)and interferon-gamma(IFN-γ). Results Low-, middle- and high- dose OYF relieved the inflammation symptoms of adjuvant arthritis rat model, decreased abdominal cavity capillary permeability of model mice significantly(except the middle dose),and reduced the serum content of TNF-α(P <0.01) and increased the serum content of IFN-γ in liver injury mice(P<0.05). The therapeutic efficacy of some dose of OYF was similar to the positive control drugs of prednisone acetate and Yujin Yinxie Tablets. Conclusion OYF has certain antiinflammatory activity and immunoregulative effect on psoriasis.