Author(s): Liu Guiping, Zhang Yu
Pages: 243-247
Year: 2016 Issue:  2
Journal: Chinese Journal of Clinicians(Electronic Version)
Keyword:  Blood platelets; Platelet microparticles; Biological functions; Clinical diseases;
Abstract: Platelet microparticles (PMP), small membrane-bound vesicles ranging in size from 0.1 to 1.0 μm, are released from activated and apoptotic platelets, and contain the plasma membrane and cytoplasmic components of the platelets. PMP are the most abundant microparticles in the bloodstream, and contain numerous biologically active molecules contributing to multiple biological functions, such as their participation in hemostasis, cancer growth, pro-inflammation, and tissue regeneration, which are the extension of the platelet’s functionin vivo. PMP may play important roles in many clinical diseases. In this review we focused on the formation, structure, and the physiological roles of the PMP and the relationship between PMP and the relevant clinical diseases.