Research on histone deacetylase as a target for anti-cancer therapy
Author(s): Li Nan, Jiang Daming, Liu Shuangping
Pages: 116-118
Year: 2016 Issue: 2
Journal: Journal of International Oncology
Keyword: Neoplasms; Histone deacetylase; Histone deacetylase inhibitor;
Abstract: The disequilibrium of histone acetylation and deacetylation may cause tumor.Histone deacetylases (HDACs) maintain the equilibrium between histone acetylation and deacetylation by catalyzing the deacetylation of histone.They are related to many regulation processes containing transcription of oncogene,cell proliferation and differentiation,apoptosis and so on.HDACs inhibitors have become the hot field of researches,more than ten different HDACs inhibitors are testing for the treatment of both hematological and solid malignancies and show obvious anti-tumor activity.
Pages: 116-118
Year: 2016 Issue: 2
Journal: Journal of International Oncology
Keyword: Neoplasms; Histone deacetylase; Histone deacetylase inhibitor;
Abstract: The disequilibrium of histone acetylation and deacetylation may cause tumor.Histone deacetylases (HDACs) maintain the equilibrium between histone acetylation and deacetylation by catalyzing the deacetylation of histone.They are related to many regulation processes containing transcription of oncogene,cell proliferation and differentiation,apoptosis and so on.HDACs inhibitors have become the hot field of researches,more than ten different HDACs inhibitors are testing for the treatment of both hematological and solid malignancies and show obvious anti-tumor activity.
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