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Optimization of Extraction Technology of Baicalin in Xiaoerjiegan Granules by Orthogonal Design
Author(s): 
Pages: 13-15
Year: Issue:  1
Journal: Pharmaceutical Journal of Chinese People's Liberation Army

Keyword:  orthogonal designbaicalinXiaoerjiegan granulesextraction process;
Abstract: Objective To optimize the extraction process of Baicalin in the herbs of Xiaoerjiegan granules.Methods Orthogonal test method was used to study the effect of the amount of extraction solvent,the time and frequencyof extraction. The content of baicalin was determined by HPLC. The optimum extraction of Baicalin was determined by choosing the yield of baicalin as the index. Results The extraction frequency had the most significant effect on the efficiency of extraction. The optimum conditions were as follows: 6 times as much water was added,extracted twice,and for extracted 3 h and 2 h respectively. Conclusion This method is simple and effective,which provide reference for the extraction of Baicalin in Xiaoerjiegan granules.
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