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Quality Standard of Tonglin Tablets
Pages: 42-44+48
Year: Issue:  1
Journal: Pharmaceutical Journal of Chinese People's Liberation Army

Keyword:  Tonglin tabletsquality standardpeoniflorinTLCHPLC;
Abstract: Objective To establish a quality standard for Tonglin tablets. Methods The chief components of the preparation were astragall radix,Salvia miltiorrhiza Bge,Ligusticum chuanxiong Hort,and Paeonia lactiflora Pall,which were identified by TLC qualitatively. The content of peoniflorin in Paeonia lactiflora Pall was determined by HPLC. The separation was performed on Agilent Eclipse Plus C18column( 4. 6 mm × 250 mm,5 μm). The mobile phase consisted of a mixture of methanol and 0. 05 mol·L- 1potassium dihydrogen phosphate solution at gradient elution. The flow rate was 1. 0 ml·min- 1,the column temperature 25 ℃,and the UV detection was performed at230 nm. Results The spots in TLC were clear without interference. A good linear relationship was shown within the range of 12. 89- 206. 30 μg·ml- 1for peoniflorin( r = 0. 9997). Conclusion This method is simple,sensitive and accurate,which can be used for quality control of Tonglin tablets.
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