Clinical observation of pilocarpine combined with latanoprost in treatment of primary acute angle closure glaucoma
Author(s): FU Yuan-dang, ZHENG Zhen-you, LIN Zai-xiong, ZHOU Ji-liang, Hospital of Integrated Chinese and Western Medicine of Changjiang Li Autonomous County, Department of Ophthalmology, Affiliated Hospital of Hainan Medical University
Pages: 210-214
Year: 2016 Issue: 2
Journal: World Phytomedicines
Keyword: Pilocarpine Nitrate Eye Drops; Latanoprost Eye Drops; glaucoma;
Abstract: Objective To investigate the clinical effect and safety of pilocarpine combined with latanoprost in treatment of primary acute angle closure glaucoma. Methods Patients(92 cases) with primary acute angle closure glaucoma in Department of Ophthalmology from Affiliated Hospital of Hainan Medical University from May 2014 to January 2015 were randomly divided into control and treatment groups, and each group had 46 cases. The patients in the control group were given Latanoprost Eye Drops, 1 drop/time, once daily. The patients in the treatment group were given Pilocarpine Nitrate Eye Drops on the basis of control group after giving Latanoprost Eye Drops for 5 min, 2 — 3 drops/time, 2 — 4 times/d. The patients in two groups were treated for 6 months. The clinical efficacy was evaluated, and the eyesight of sick eyes, pupil diameter, ocular hypertension, hemodynamics indexes end-diastolic velocity(EDV), systolic peak flow velocity(PSV), and vascular resistance index(RI), and adverse reactions in two groups were compared before and after treatment. Results After treatment, the clinical efficacies in the control and treatment groups were 82.61% and 95.65%, respectively, and there were differences between two groups(P < 0.05). After treatment for 1, 3, and 6 months, eyesight of sick eyes and pupil diameter in two groups were significantly improved, and the difference was statistically significant in the same group(P < 0.05). After treatment, eyesight of sick eyes and pupil diameter in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). The ocular hypertension of patients in the control group after treatment for 3, and 6 months, and in the treatment group after treatment for 1, 3, and 6 months was significantly decreased. And the ocular hypertension in the treatment group was better than that in the control group, with significant difference between two groups(P < 0.05). After treatment for 1, 3, and 6 months, EDV and PSV in the treatment group was higher than that in the control group, and RI was lower than that in the control group, and the difference was statistically significant in the same group(P < 0.05). And the EDV, PSV, and RI in the treatment group were better than those in the control group with significant difference(P < 0.05). Conclusion Pilocarpine combined with latanoprost has clinical curative effect in treatment of primary acute angle closure glaucoma, and can obviously improve vision, and also can improve the field of vision with high safety, which has a certain clinical application value.
Pages: 210-214
Year: 2016 Issue: 2
Journal: World Phytomedicines
Keyword: Pilocarpine Nitrate Eye Drops; Latanoprost Eye Drops; glaucoma;
Abstract: Objective To investigate the clinical effect and safety of pilocarpine combined with latanoprost in treatment of primary acute angle closure glaucoma. Methods Patients(92 cases) with primary acute angle closure glaucoma in Department of Ophthalmology from Affiliated Hospital of Hainan Medical University from May 2014 to January 2015 were randomly divided into control and treatment groups, and each group had 46 cases. The patients in the control group were given Latanoprost Eye Drops, 1 drop/time, once daily. The patients in the treatment group were given Pilocarpine Nitrate Eye Drops on the basis of control group after giving Latanoprost Eye Drops for 5 min, 2 — 3 drops/time, 2 — 4 times/d. The patients in two groups were treated for 6 months. The clinical efficacy was evaluated, and the eyesight of sick eyes, pupil diameter, ocular hypertension, hemodynamics indexes end-diastolic velocity(EDV), systolic peak flow velocity(PSV), and vascular resistance index(RI), and adverse reactions in two groups were compared before and after treatment. Results After treatment, the clinical efficacies in the control and treatment groups were 82.61% and 95.65%, respectively, and there were differences between two groups(P < 0.05). After treatment for 1, 3, and 6 months, eyesight of sick eyes and pupil diameter in two groups were significantly improved, and the difference was statistically significant in the same group(P < 0.05). After treatment, eyesight of sick eyes and pupil diameter in the treatment group were significantly better than those in the control group, with significant difference between two groups(P < 0.05). The ocular hypertension of patients in the control group after treatment for 3, and 6 months, and in the treatment group after treatment for 1, 3, and 6 months was significantly decreased. And the ocular hypertension in the treatment group was better than that in the control group, with significant difference between two groups(P < 0.05). After treatment for 1, 3, and 6 months, EDV and PSV in the treatment group was higher than that in the control group, and RI was lower than that in the control group, and the difference was statistically significant in the same group(P < 0.05). And the EDV, PSV, and RI in the treatment group were better than those in the control group with significant difference(P < 0.05). Conclusion Pilocarpine combined with latanoprost has clinical curative effect in treatment of primary acute angle closure glaucoma, and can obviously improve vision, and also can improve the field of vision with high safety, which has a certain clinical application value.
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